April 25, 2018

Subthreshold amyloid predicts tau deposition in aging

Current approaches to the early detection of Alzheimer’s disease (AD) rely upon classifying individuals as “positive” or “negative” for biomarkers related to the core pathology of beta-amyloid (Aβ). However, the accumulation of Aβ begins slowly, years before biomarkers become abnormal. We used longitudinal [11C] Pittsburgh Compound B (PIB) PET and neuropsychological assessment to investigate the earliest changes in AD pathology and how it affects memory in cognitively normal older humans. {read more here}