May 5, 2015

Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer

Brain metastases are common in human epidermal growth factor receptor (Her)-2-positive breast cancer. Drug access to brain metastases and normal brain is key to management of cranial disease.  In this study, positron emission tomography (PET) scanning after administration of radiolabelled lapatinib was used to obtain direct evidence of cranial drug access. {read more here}