Hypoxia may have more of an impact in SBRT due to the fewer number of treatment fractions, which reduces the opportunity for re-oxygenation of hypoxic tumour cells. To investigate this premise, researchers from Yale University of School of Medicine have used ¹⁸F-FMISO PET to quantify changes in tumour hypoxia in response to SBRT Int. J. Radiat. Oncol. Bio. Phys. 102 174. {read more here}